Two sample MR report

Telomere_length against aparc-a2009s lh volume G-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0741688	0.1114931	0.5131426
Weighted median	23	-0.0305731	0.0622261	0.6231982
Inverse variance weighted	23	-0.0631510	0.0425792	0.1380364
Simple mode	23	-0.0202178	0.1334018	0.8809188
Weighted mode	23	0.0349243	0.1000843	0.7304457

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.41918	21	0.1909146
Inverse variance weighted	26.43368	22	0.2335284

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006765	0.0063014	0.915525

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008811	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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