Two sample MR report

Telomere_length against aparc-a2009s lh volume G-subcallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1049324	0.1027948	0.3189683
Weighted median	23	-0.0183466	0.0554100	0.7405637
Inverse variance weighted	23	-0.0051080	0.0402729	0.8990722
Simple mode	23	-0.0612294	0.0930211	0.5172186
Weighted mode	23	-0.0208439	0.0655115	0.7533555

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.45493	21	0.3737133
Inverse variance weighted	23.64505	22	0.3661064

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061292	0.0058098	0.3034164

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000717	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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