Two sample MR report

Telomere_length against aparc-a2009s lh volume G-rectus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0563295	0.1231302	0.6520242
Weighted median	23	0.0414900	0.0622020	0.5047584
Inverse variance weighted	23	-0.0170237	0.0474766	0.7199160
Simple mode	23	0.0154824	0.1234100	0.9013029
Weighted mode	23	0.0223517	0.0814081	0.7862129

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.21945	21	0.0556212
Inverse variance weighted	32.86210	22	0.0638402

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045039	0.0069591	0.5245152

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010016	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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