Two sample MR report

Telomere_length against aparc-a2009s lh volume G-precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2600905	0.1360942	0.0697371
Weighted median	23	-0.1079398	0.0578538	0.0620788
Inverse variance weighted	23	-0.0310385	0.0559427	0.5790127
Simple mode	23	-0.0899249	0.1002466	0.3794109
Weighted mode	23	-0.1049052	0.0664218	0.1285208

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.36271	21	0.0088806
Inverse variance weighted	45.62913	22	0.0022065

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0140638	0.0076917	0.0817269

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001402	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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