Two sample MR report

Telomere_length against aparc-a2009s lh volume G-precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2250060	0.1058120	0.0454857
Weighted median	23	-0.1559458	0.0571906	0.0063957
Inverse variance weighted	23	-0.1261454	0.0413772	0.0022986
Simple mode	23	-0.2764910	0.1089872	0.0187857
Weighted mode	23	-0.1525597	0.0689551	0.0376204

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.79480	21	0.3031068
Inverse variance weighted	24.96216	22	0.2988876

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00607	0.0059803	0.3216528

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010759	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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