Two sample MR report

Telomere_length against aparc-a2009s lh volume G-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2408523	0.1031755	0.0295859
Weighted median	23	-0.0762110	0.0598090	0.2025782
Inverse variance weighted	23	-0.0735030	0.0422032	0.0815702
Simple mode	23	-0.1510290	0.0932868	0.1197007
Weighted mode	23	-0.1256915	0.0636329	0.0609169

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.62318	21	0.3643939
Inverse variance weighted	25.96816	22	0.2530514

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0102752	0.0058312	0.0926044

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008954	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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