Two sample MR report

Telomere_length against aparc-a2009s lh volume G-pariet-inf-Supramar

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1238622	0.0994043	0.2264705
Weighted median	23	-0.1491230	0.0532327	0.0050891
Inverse variance weighted	23	-0.1414847	0.0388448	0.0002702
Simple mode	23	-0.0617889	0.0950356	0.5223171
Weighted mode	23	-0.1299024	0.0650516	0.0583533

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.45552	21	0.6831515
Inverse variance weighted	17.49261	22	0.7356120

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001082	0.0056181	0.8491261

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000932	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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