Two sample MR report

Telomere_length against aparc-a2009s lh volume G-pariet-inf-Angular

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1776467	0.1169573	0.1437000
Weighted median	23	-0.0483503	0.0594629	0.4161512
Inverse variance weighted	23	-0.0221883	0.0468172	0.6355464
Simple mode	23	-0.1042735	0.1070817	0.3407543
Weighted mode	23	-0.0778900	0.0641199	0.2373374

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.07004	21	0.1123302
Inverse variance weighted	31.95648	22	0.0781409

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095451	0.0066101	0.1634921

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009782	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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