Two sample MR report

Telomere_length against aparc-a2009s lh volume G-parietal-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0718285	0.0994050	0.4779061
Weighted median	23	-0.1154001	0.0584256	0.0482496
Inverse variance weighted	23	-0.0668190	0.0388451	0.0854072
Simple mode	23	-0.1304871	0.1068232	0.2348161
Weighted mode	23	-0.1412789	0.0866164	0.1171062

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.60852	21	0.6102370
Inverse variance weighted	18.61152	22	0.6691785

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003076	0.0056182	0.9568568

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006537	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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