Two sample MR report

Telomere_length against aparc-a2009s lh volume G-orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1757853	0.1339453	0.2035605
Weighted median	23	-0.0663196	0.0608708	0.2759271
Inverse variance weighted	23	-0.0442385	0.0525066	0.3994896
Simple mode	23	0.0109384	0.1093605	0.9212330
Weighted mode	23	-0.1002684	0.0727120	0.1817605

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.12833	21	0.0124495
Inverse variance weighted	40.19513	22	0.0102579

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.008077	0.0075703	0.2981172

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012571	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8