Two sample MR report

Telomere_length against aparc-a2009s lh volume G-oc-temp-med-Parahip

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0684973	0.1086584	0.5352391
Weighted median	23	-0.0524905	0.0547733	0.3379002
Inverse variance weighted	23	-0.0480067	0.0415261	0.2476556
Simple mode	23	-0.0908676	0.0872071	0.3087390
Weighted mode	23	-0.0586371	0.0594986	0.3350840

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.09095	21	0.2432465
Inverse variance weighted	25.14110	22	0.2903750

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012581	0.0061411	0.8396482

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008081	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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