Two sample MR report

Telomere_length against aparc-a2009s lh volume G-oc-temp-med-Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0810177	0.1000180	0.4270062
Weighted median	23	-0.0001173	0.0590010	0.9984142
Inverse variance weighted	23	-0.0241757	0.0388451	0.5337045
Simple mode	23	0.0560494	0.1126961	0.6238769
Weighted mode	23	0.0619741	0.0774921	0.4324083

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.25962	21	0.4431901
Inverse variance weighted	21.64553	22	0.4812087

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034901	0.0056528	0.5436012

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006677	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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