Two sample MR report

Telomere_length against aparc-a2009s lh volume G-oc-temp-lat-fusifor

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0742085	0.1002318	0.4672740
Weighted median	23	0.0111781	0.0574120	0.8456285
Inverse variance weighted	23	-0.0270838	0.0393504	0.4912800
Simple mode	23	-0.1980300	0.1113632	0.0891906
Weighted mode	23	0.0271440	0.0720601	0.7100162

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.35034	21	0.4377353
Inverse variance weighted	22.57578	22	0.4260049

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0062193	0.0056649	0.2846875

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006988	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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