Two sample MR report

Telomere_length against aparc-a2009s lh volume G-occipital-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2044509	0.1076525	0.0713659
Weighted median	23	-0.0798071	0.0580704	0.1693436
Inverse variance weighted	23	-0.0706044	0.0428488	0.0994025
Simple mode	23	-0.0761219	0.0938632	0.4260597
Weighted mode	23	-0.0794007	0.0684141	0.2582480

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.62885	21	0.2635963
Inverse variance weighted	26.76857	22	0.2201487

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0082182	0.0060843	0.1911614

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009113	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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