Two sample MR report

Telomere_length against aparc-a2009s lh volume G-occipital-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1648132	0.0994052	0.1121830
Weighted median	23	-0.0634253	0.0581790	0.2756364
Inverse variance weighted	23	0.0089229	0.0388451	0.8183216
Simple mode	23	-0.1038169	0.1173480	0.3858896
Weighted mode	23	-0.1038169	0.0778431	0.1959567

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.76059	21	0.7255130
Inverse variance weighted	20.36577	22	0.5601719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0106674	0.0056181	0.0714271

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006187	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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