Two sample MR report

Telomere_length against aparc-a2009s lh volume G-insular-short

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1296581	0.1212899	0.2972072
Weighted median	23	-0.0701357	0.0570961	0.2193048
Inverse variance weighted	23	-0.0047426	0.0476674	0.9207460
Simple mode	23	-0.0911298	0.0785963	0.2586960
Weighted mode	23	-0.0654097	0.0579899	0.2714926

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.26409	21	0.0693738
Inverse variance weighted	33.12778	22	0.0600989

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076697	0.006855	0.2758373

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010043	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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