Two sample MR report

Telomere_length against aparc-a2009s lh volume G-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1976473	0.1223534	0.1211539
Weighted median	23	-0.1720807	0.0581068	0.0030619
Inverse variance weighted	23	-0.0971050	0.0475915	0.0413120
Simple mode	23	-0.2016084	0.1013969	0.0593603
Weighted mode	23	-0.1699453	0.0707175	0.0251249

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.81549	21	0.0611161
Inverse variance weighted	33.02288	22	0.0615527

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061733	0.0069152	0.3821233

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00119	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8