Two sample MR report

Telomere_length against aparc-a2009s lh volume G-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2181253	0.1163207	0.0747390
Weighted median	23	-0.1272485	0.0609904	0.0369451
Inverse variance weighted	23	-0.1385413	0.0449907	0.0020746
Simple mode	23	-0.0252053	0.1109334	0.8223577
Weighted mode	23	-0.1365223	0.0720482	0.0713271

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.75640	21	0.1199739
Inverse variance weighted	29.51291	22	0.1307915

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048865	0.0065742	0.4655477

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012797	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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