Two sample MR report

Telomere_length against aparc-a2009s lh volume G-front-inf-Triangul

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1272058	0.0994050	0.2146185
Weighted median	23	-0.0945530	0.0536216	0.0778434
Inverse variance weighted	23	-0.0682893	0.0388451	0.0787494
Simple mode	23	-0.0629399	0.0911360	0.4970303
Weighted mode	23	-0.1099332	0.0625926	0.0929451

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.56962	21	0.7933241
Inverse variance weighted	15.98421	22	0.8166685

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036175	0.0056182	0.5266174

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000578	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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