Two sample MR report

Telomere_length against aparc-a2009s lh volume G-front-inf-Orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0825061	0.0994083	0.4158902
Weighted median	23	0.0398704	0.0532002	0.4535916
Inverse variance weighted	23	0.0366080	0.0388464	0.3459992
Simple mode	23	0.0485127	0.0864671	0.5804310
Weighted mode	23	0.0284352	0.0602364	0.6415323

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.98784	21	0.9090492
Inverse variance weighted	14.68237	22	0.8755049

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073136	0.0056183	0.2071052

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004718	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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