Two sample MR report

Telomere_length against aparc-a2009s lh volume G-front-inf-Opercular

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2247372	0.0994032	0.0345091
Weighted median	23	-0.1177637	0.0578737	0.0418671
Inverse variance weighted	23	-0.0863825	0.0388446	0.0261623
Simple mode	23	-0.1140928	0.1147388	0.3308547
Weighted mode	23	-0.1686403	0.0932931	0.0843567

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.54193	21	0.8452157
Inverse variance weighted	16.82834	22	0.7727635

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084951	0.0056181	0.1454153

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006598	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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