Two sample MR report

Telomere_length against aparc-a2009s lh volume G-cingul-Post-ventral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0515482	0.0994096	0.6095006
Weighted median	23	0.0269837	0.0566767	0.6340038
Inverse variance weighted	23	0.0039454	0.0388474	0.9191056
Simple mode	23	-0.0044285	0.0957432	0.9635254
Weighted mode	23	0.0365003	0.0640091	0.5742955

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.87587	21	0.7186026
Inverse variance weighted	17.14650	22	0.7552243

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029228	0.0056185	0.6083507

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005199	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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