Two sample MR report

Telomere_length against aparc-a2009s lh volume G-cingul-Post-dorsal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1329622	0.1272549	0.3079715
Weighted median	23	-0.0024661	0.0530602	0.9629293
Inverse variance weighted	23	-0.0220886	0.0496099	0.6561414
Simple mode	23	0.0109893	0.0805589	0.8927349
Weighted mode	23	0.0067092	0.0576210	0.9083629

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.41302	21	0.0327146
Inverse variance weighted	35.88118	22	0.0312684

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068076	0.0071921	0.3546422

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010968	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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