Two sample MR report

Telomere_length against aparc-a2009s lh volume G+S-transv-frontopol

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0566196	0.0994062	0.5750067
Weighted median	23	-0.0315735	0.0570603	0.5800331
Inverse variance weighted	23	-0.0389084	0.0388452	0.3165247
Simple mode	23	0.0412739	0.0956236	0.6702117
Weighted mode	23	-0.0070414	0.0669413	0.9171795

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.78012	21	0.5992426
Inverse variance weighted	18.81759	22	0.6565638

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010875	0.0056182	0.8483796

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006006	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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