Two sample MR report

Telomere_length against aparc-a2009s lh volume G+S-subcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2319918	0.1124383	0.0516659
Weighted median	23	-0.1904874	0.0570707	0.0008446
Inverse variance weighted	23	-0.1271116	0.0439650	0.0038378
Simple mode	23	-0.0408239	0.1036323	0.6974246
Weighted mode	23	-0.1555020	0.0655370	0.0268200

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.86858	21	0.1752456
Inverse variance weighted	28.18244	22	0.1697134

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064397	0.0063548	0.3224241

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011784	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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