Two sample MR report

Telomere_length against aparc-a2009s lh volume G+S-paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1911826	0.1192594	0.1238521
Weighted median	23	-0.1493488	0.0642919	0.0201802
Inverse variance weighted	23	-0.0768731	0.0466927	0.0996893
Simple mode	23	0.1884513	0.1444868	0.2056193
Weighted mode	23	-0.1856544	0.0896485	0.0503002

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.22710	21	0.0875186
Inverse variance weighted	31.78781	22	0.0810863

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070187	0.0067403	0.3095808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010819	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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