Two sample MR report

Telomere_length against aparc-a2009s lh volume G+S-occipital-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0467634	0.1312959	0.7252684
Weighted median	23	-0.0795858	0.0640037	0.2136999
Inverse variance weighted	23	-0.0113064	0.0502308	0.8219093
Simple mode	23	-0.1133912	0.1431395	0.4367193
Weighted mode	23	-0.1512767	0.0887491	0.1023636

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.63807	21	0.0185173
Inverse variance weighted	36.78823	22	0.0249528

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021771	0.0074206	0.77211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011173	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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