Two sample MR report

Telomere_length against aparc-a2009s lh volume G+S-frontomargin

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0797962	0.0994056	0.4311208
Weighted median	23	-0.0211180	0.0615251	0.7314163
Inverse variance weighted	23	-0.0428734	0.0388452	0.2697239
Simple mode	23	-0.1102737	0.1118762	0.3350093
Weighted mode	23	-0.0922609	0.0925461	0.3296433

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.11010	21	0.7044105
Inverse variance weighted	18.90739	22	0.6510401

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0075319	0.0056182	0.1943646

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006098	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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