Two sample MR report

Telomere_length against aparc-a2009s lh volume G+S-cingul-Mid-Post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1399895	0.0994066	0.1736896
Weighted median	23	-0.0688286	0.0581388	0.2364656
Inverse variance weighted	23	-0.0772349	0.0388461	0.0467861
Simple mode	23	0.0000567	0.0926635	0.9995175
Weighted mode	23	-0.0355190	0.0738800	0.6354291

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.24561	21	0.5057554
Inverse variance weighted	20.71597	22	0.5383463

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038532	0.0056183	0.500325

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007475	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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