Two sample MR report

Telomere_length against aparc-a2009s lh volume G+S-cingul-Mid-Ant

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0469557 0.1054853 0.6607736
Weighted median 23 -0.1129511 0.0598195 0.0589994
Inverse variance weighted 23 -0.0502326 0.0402744 0.2123034
Simple mode 23 -0.1346806 0.1048859 0.2124772
Weighted mode 23 -0.1319889 0.0779034 0.1043268

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.64719 21 0.3104655
Inverse variance weighted 23.64847 22 0.3659220

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0002012 0.0059618 0.9733964

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007673 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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