Two sample MR report

Telomere_length against aparc-a2009s lh volume G+S-cingul-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0125763	0.1083066	0.9086622
Weighted median	23	-0.0799164	0.0632834	0.2066493
Inverse variance weighted	23	-0.0945628	0.0424728	0.0259853
Simple mode	23	-0.0333976	0.1257232	0.7929872
Weighted mode	23	-0.0918571	0.1228003	0.4623701

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.93099	21	0.2501651
Inverse variance weighted	26.30211	22	0.2389371

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065784	0.0061213	0.2947134

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009765	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8