Two sample MR report

Telomere_length against aparc-a2009s lh volume G-Ins-lg+S-cent-ins

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1507808	0.1124336	0.1942251
Weighted median	23	-0.0787277	0.0550075	0.1523675
Inverse variance weighted	23	-0.0427202	0.0440263	0.3318793
Simple mode	23	-0.0750889	0.0953540	0.4394057
Weighted mode	23	-0.0750889	0.0666368	0.2719518

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.86425	21	0.1753917
Inverse variance weighted	28.25890	22	0.1672591

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066349	0.0063545	0.3082972

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008929	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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