Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-temporal-transverse

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1646748	0.1014181	0.1193520
Weighted median	23	-0.0300961	0.0576262	0.6014867
Inverse variance weighted	23	-0.0411275	0.0403033	0.3075159
Simple mode	23	-0.0427235	0.0905338	0.6416404
Weighted mode	23	-0.0493796	0.0717654	0.4986005

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.85559	21	0.4078720
Inverse variance weighted	23.67842	22	0.3643088

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075859	0.005732	0.1999207

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007515	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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