Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-temporal-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1768504	0.1050301	0.1070267
Weighted median	23	-0.0429765	0.0548400	0.4332340
Inverse variance weighted	23	-0.0114397	0.0428034	0.7892676
Simple mode	23	0.1198462	0.1043204	0.2629646
Weighted mode	23	-0.0710430	0.0717287	0.3327277

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.44401	21	0.3207690
Inverse variance weighted	26.71199	22	0.2223702

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0101562	0.0059361	0.1018267

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000812	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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