Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0982403	0.1032354	0.3521175
Weighted median	23	-0.0063264	0.0569451	0.9115402
Inverse variance weighted	23	-0.0297498	0.0398988	0.4558897
Simple mode	23	-0.1501891	0.0973623	0.1371955
Weighted mode	23	-0.0087565	0.0603598	0.8859748

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.64907	21	0.3629706
Inverse variance weighted	23.20935	22	0.3899903

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042053	0.0058346	0.4790108

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007211	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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