Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-subparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2263556	0.1308482	0.0983183
Weighted median	23	0.0481281	0.0610308	0.4303531
Inverse variance weighted	23	0.0176596	0.0546215	0.7464617
Simple mode	23	0.0382568	0.1148635	0.7422397
Weighted mode	23	0.0465089	0.1004964	0.6480586

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.38830	21	0.0197675
Inverse variance weighted	43.50057	22	0.0040927

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0149827	0.0073953	0.0556598

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013243	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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