Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-suborbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1435941	0.1045091	0.1839350
Weighted median	23	-0.0647105	0.0526162	0.2187503
Inverse variance weighted	23	-0.0128352	0.0416189	0.7577782
Simple mode	23	-0.0429594	0.0802919	0.5979893
Weighted mode	23	-0.0734144	0.0595157	0.2303950

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.21147	21	0.3328078
Inverse variance weighted	25.25360	22	0.2851018

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080285	0.0059066	0.188486

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007685	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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