Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-precentral-sup-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1029070	0.1067348	0.3459494
Weighted median	23	-0.1013552	0.0564955	0.0728069
Inverse variance weighted	23	-0.0278109	0.0413132	0.5008376
Simple mode	23	-0.1358194	0.0961270	0.1716727
Weighted mode	23	-0.1166439	0.0650816	0.0868541

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.21078	21	0.2829580
Inverse variance weighted	24.88434	22	0.3026376

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046109	0.0060324	0.4531612

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007695	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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