Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-precentral-inf-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1581592	0.0994061	0.1265427
Weighted median	23	-0.0098123	0.0564607	0.8620310
Inverse variance weighted	23	-0.0109023	0.0392946	0.7814338
Simple mode	23	-0.0233047	0.0899398	0.7979565
Weighted mode	23	-0.0199831	0.0650345	0.7615278

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.92181	21	0.5262186
Inverse variance weighted	22.51175	22	0.4297219

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090415	0.0056182	0.1224751

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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