Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1573219	0.1039770	0.1451733
Weighted median	23	-0.0580329	0.0609088	0.3407002
Inverse variance weighted	23	-0.0216351	0.0415537	0.6026072
Simple mode	23	-0.1521561	0.1028572	0.1532391
Weighted mode	23	-0.0636524	0.0674480	0.3555600

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.97579	21	0.3452704
Inverse variance weighted	25.17475	22	0.2887910

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083312	0.0058766	0.1709478

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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