Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-pericallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0134807	0.1114865	0.9049059
Weighted median	23	-0.0207765	0.0574712	0.7177171
Inverse variance weighted	23	0.0114914	0.0425645	0.7871795
Simple mode	23	0.0125884	0.0958476	0.8967021
Weighted mode	23	-0.0213481	0.0649362	0.7454494

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.41401	21	0.1911007
Inverse variance weighted	26.41448	22	0.2343123

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001221	0.0063009	0.9847171

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000803	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8