Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-parieto-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3346276	0.1015217	0.0034409
Weighted median	23	-0.0297291	0.0604663	0.6229564
Inverse variance weighted	23	-0.0298677	0.0475738	0.5301233
Simple mode	23	0.0829841	0.1095857	0.4569325
Weighted mode	23	-0.0475581	0.0761789	0.5388546

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.90474	21	0.4050173
Inverse variance weighted	32.99864	22	0.0618930

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0187123	0.0057378	0.0037324

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010178	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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