Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-orbital-med-olfact

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0501393	0.0994075	0.6192447
Weighted median	23	0.0384947	0.0539427	0.4754609
Inverse variance weighted	23	-0.0070641	0.0388461	0.8557018
Simple mode	23	0.0306173	0.0990767	0.7602091
Weighted mode	23	0.0408152	0.0610367	0.5106436

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.61480	21	0.6098354
Inverse variance weighted	19.00561	22	0.6449819

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035123	0.0056183	0.5386059

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005769	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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