Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-orbital-lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0500809	0.1009875	0.6251071
Weighted median	23	0.0783766	0.0567806	0.1674816
Inverse variance weighted	23	0.0643998	0.0388457	0.0973505
Simple mode	23	0.0092299	0.1090842	0.9333350
Weighted mode	23	0.0787689	0.0631096	0.2251050

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.67329	21	0.4185414
Inverse variance weighted	21.69778	22	0.4780465

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008792	0.0057076	0.8790514

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007408	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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