Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-orbital-H-Shaped

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0019464	0.1191647	0.9871220
Weighted median	23	-0.0348067	0.0554087	0.5298845
Inverse variance weighted	23	-0.0150906	0.0455220	0.7402661
Simple mode	23	-0.0372930	0.1057829	0.7277863
Weighted mode	23	-0.0285700	0.0758769	0.7101291

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.17739	21	0.0884810
Inverse variance weighted	30.21205	22	0.1134008

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010461	0.0067349	0.8780518

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00092	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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