Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-oc-temp-med+Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2232227	0.1241285	0.0865184
Weighted median	23	-0.1084613	0.0581531	0.0621675
Inverse variance weighted	23	-0.0289711	0.0505471	0.5665423
Simple mode	23	-0.1442326	0.1177953	0.2337388
Weighted mode	23	-0.1308761	0.0689462	0.0708622

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.74506	21	0.0491215
Inverse variance weighted	37.25196	22	0.0221928

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.011927	0.0070155	0.1038761

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011457	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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