Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-oc-temp-lat

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0518520 0.1088803 0.6388279
Weighted median 23 0.0335114 0.0572458 0.5582826
Inverse variance weighted 23 0.0019812 0.0418140 0.9622085
Simple mode 23 0.0489232 0.0912463 0.5972236
Weighted mode 23 0.0489232 0.0768142 0.5307604

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 25.19422 21 0.2388501
Inverse variance weighted 25.49128 22 0.2741629

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0030621 0.0061537 0.6239365

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007724 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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