Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-oc-sup+transversal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2569775	0.1110460	0.0308724
Weighted median	23	-0.0101486	0.0630053	0.8720341
Inverse variance weighted	23	-0.0383881	0.0467860	0.4119290
Simple mode	23	-0.0271398	0.1194968	0.8224301
Weighted mode	23	-0.0131871	0.0892469	0.8838783

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.20775	21	0.1986381
Inverse variance weighted	31.91504	22	0.0788562

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0134215	0.0062761	0.0443873

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009966	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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