Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-oc-middle+Lunatus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2264702	0.0994047	0.0332805
Weighted median	23	0.0097542	0.0610978	0.8731572
Inverse variance weighted	23	-0.0336265	0.0392055	0.3910596
Simple mode	23	0.0793202	0.1272600	0.5395010
Weighted mode	23	-0.1099834	0.0750380	0.1568772

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.96846	21	0.6509990
Inverse variance weighted	22.41031	22	0.4356387

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0118407	0.0056182	0.0472605

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007018	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8