Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-occipital-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1670720	0.1006860	0.1119096
Weighted median	23	-0.0989774	0.0595668	0.0965888
Inverse variance weighted	23	-0.0436317	0.0400319	0.2757472
Simple mode	23	-0.1205794	0.1110029	0.2891177
Weighted mode	23	-0.1442657	0.0853602	0.1051348

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.5451	21	0.4261168
Inverse variance weighted	23.3651	22	0.3813654

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075792	0.0056906	0.1971698

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007462	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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